Practicing medicine for over 40 years, Dr. Minkoff has worked as an attending physician in infectious disease, co-directed a neo-natal intensive care unit, and worked as an ER physician.  In 1997 he opened Lifeworks Wellness Center, now one of the foremost alternative medicine clinics in the United States and now, in addition to seeing hundreds of patients per week, he travels the country as a keynote speaker at numerous medical conferences every year.

Dr Minkoff is also an avid athlete, having completed 42 full Ironman triathlons and continues to compete in them even at 70 years old.