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The Link Between Oxidative Stress and Chronic Inflammation

by Dr. David Minkoff October 08, 2020 4 min read 0 Comments

The Link Between Oxidative Stress and Chronic Inflammation

One of the founding fathers of the United States, Thomas Jefferson, is known for his statement: “knowledge is power.” We agree with this statement, which is why we devote so much time and effort to helping YOU gain the knowledge you need to achieve greater control of your overall health.

Today we’re going to discuss two of the most common, destructive conditions that the human body is subjected to: Oxidative stress and chronic inflammation.

And not only are we going to explain WHAT they are (in understandable terms), but we’re going to explain the hidden link between these two conditions and provide you with some effective, doctor-proven advice as to how to avoid and treat them.

Oxidative Stress and Chronic Inflammation: The Downward Spiral

First things first, let’s discuss the basics of these two physical conditions.

Inflammation is a natural response of the human immune system to fight what the body considers to be a foreign invader. Inflammation can occur anywhere in the body, and often has visible symptoms such as pain, swelling, redness, heat, and congestion (inflammation in the sinuses).

The physiological actions of inflammation involve:

  • Raising the temperature of the area
  • Widening blood capillaries
  • Bringing fluid and white blood cells to kill and flush out pathogens

Inflammation is effective and healthy when it has a definite start and end, or acuteinflammation. It becomes a problem when parts of your body become inflamed and remain in that condition, at which point the inflammation becomes chronic. To make the situation worse, when your immune system starts treating healthy cells and nutrients as pathogens, you develop an autoimmune disease where your body starts attacking healthy cells.

Oxidative stress  is a condition in which your body has an excess of free radicals, and they begin attacking and damaging the healthy cells and proteins. Free radicals can alter the DNA of your cells and trigger mutations, as well as creating biological conditions that lead to severe illnesses or cellular aging. Some of the many diseases and conditions linked to oxidative stress include:

  • Cancer
  • Diabetes
  • Rheumatoid arthritis
  • Heart disease
  • Stroke


Here’s the kicker: The biological process of inflammation causes the production of free radicals, and oxidative stress causes inflammation. Left unchecked, these two conditions cause a synergistic downward spiral of worsening health conditions.

The Link Between Oxidative Stress and Inflammation Explained

Let’s talk science for a minute and see how exactly these two conditions relate.

One of the most important types of white blood cells in your immune system is called a macrophage. These cells primarily detect and destroy pathogens, but they also help other immune cells identify pathogens and trigger inflammation (essentially calling for backup). However, one of the byproducts of this destruction of pathogens by macrophages is the production of free radicals, including the highly toxic hydroxyl radical.

In most cases, the quantity of free radicals produced is minor, and they are easily taken care of by antioxidants in your blood (such as Vitamin C, H2, and several others).

But what about when inflammation goes on too long, and your body is already deficient in antioxidants? Yes, you guessed it, chronic inflammation leads to oxidative stress.

When free radicals are left to rampage throughout your body, several things tend to happen:

  • Your cells become damaged
  • The genetic expression of your cells is altered
  • Proteins throughout your blood are altered

All three forms of biological destruction in your system cause inflammation, which, again, causes the production of more free radicals.

This interrelation between oxidative stress and inflammation is one of the primary causes of disease and illness in the human body.


How to Reduce Oxidative Stress and “Chill” Inflammation

Two of the easiest ways to reduce oxidative stress and restore a healthy balance to your body systems are:

Avoid foods and actions that trigger the production of free radicals.

Common foods and life activities that lead to an overproduction of free radicals include:

  • Fried foods
  • Foods high in preservatives
  • Processed carbohydrates that have a high glycemic index
  • Smoking
  • Exposure to UV radiation
  • Toxic chemicals
  • Pesticides
  • Air pollution

Avoiding these foods, exposures, and habits can help lower oxidative stress in your body and prevent the condition from occurring in the first place.


Supply your body with the antioxidants it needs to combat excessive free radicals

Antioxidants can be supplied to your body through the food you eat or from supplements. Vitamin C, the polyphenols found in vegetables, Vitamin E, and many other common nutrients are effective antioxidants and can make a significant impact in reducing oxidative stress and inflammation.

Healthline has an excellent list of foods that are high in antioxidants, which we strongly recommend.

But there is a secret weapon in the fight against oxidative stress that has recently come to the forefront of scientific research: Molecular hydrogen (H2 gas).

Molecular hydrogen is a safe, gentle, and selectiveantioxidant that targets only the most toxic and damaging free radicals – including hydroxyl.

You see, not all free radicals are bad. They are, in fact, a key factor in many healthy biological processes. They only become a real problem when there is an imbalance – and this imbalance can also go in the opposite direction. Too much antioxidant intake causes an entirely different set of physiological problems for your body systems.

Molecular hydrogen bypasses this problem entirely because it is selective. It corrects oxidative stress without causing any collateral damage. It promotes cellular homeostasis and is highly effective as a daily supplement to prevent and treat oxidative stress.

H2 Infuse is a revolutionary form of supplemental H2 gas that comes in the form of tablets that dissolve in water. A single tablet placed in 500mL of water supplies your body with roughly 8ppm of molecular hydrogen – one of the highest concentrations available.

We hope that the information in this article was useful, and here’s to YOU achieving optimal health!




*This website, including products, articles, and educational content are not intended to diagnose, cure, or prevent any disease. The statements on this website have not been evaluated by the food and drug administration. This website does not provide medical advice. The information contained in this website is for general information purposes only.

Dr. David Minkoff
Dr. David Minkoff

Dr. David Minkoff graduated from the University of Wisconsin Medical School in 1974 and was elected to the “Phi Beta Kappa” of medical schools, the prestigious Alpha Omega Alpha Honors Medical Fraternity for very high academic achievement. He then completed both a Pediatric Residency and Fellowship in Infectious Disease at the University of California at San Diego.

He worked at the University of California and Children’s Hospitals in San Diego as an attending physician in infectious disease while conducting original research on Ribaviron, a broad spectrum anti-viral agent to fight disease. He also co-directed a neo-natal intensive care unit and worked in emergency medicine.

In 1992, Dr Minkoff’s wife Sue, a Registered Nurse, became interested in nutrition and health and began to go to lectures from some of the experts in the field. At the time, Dr Minkoff was pretty fixed in his view of traditional medicine and it took a lot of convincing to get him to come to one of these lectures. After hearing Dr Jeffrey Bland speak, Dr Minkoff had a eureka moment and began pursuing the alternative field with a vengeance. Based on this new knowledge Dr Minkoff and his wife set up a small clinic in 1997 to help some friends with their medical problems. What began as an experiment blossomed into Lifeworks Wellness Center, one of the most successful clinics for complementary medicine in the United States. In the process, he gained expertise in Biological medicine, integrative oncology, heavy metal detoxification, anti-aging medicine, hormone replacement therapy, functional medicine, energy medicine, neural and prolotherapy, homeopathy and optimum nutrition. He studied under the masters in each of these disciplines until he became an expert in his own right. Dr Minkoff is one of the most in demand speakers in the field and wrote an Amazon best selling book called The Search For The Perfect Protein.

The demand for the products and protocols he discovered became a catalyst for founding BodyHealth.Com, a nutrition company that now manufactures and distributes cutting-edge nutritional solutions for the many health problems of today. Dr. Minkoff writes two free online newsletters, “The Optimum Health Report” and ”The BodyHealth Fitness Newsletter”, to help others learn about optimum health and fitness.

Dr. Minkoff is an avid athlete himself and has completed 44 Ironman Triathlons. To keep his fitness maximal, he lives the lifestyle he teachers to others and tries to set an example for others, so they can enjoy a life free of pain and full of energy.

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